A pair of ACC squads aiming for their third straight victories will clash on Monday's college basketball schedule as the Duke Blue Devils host the Syracuse Orange. No. 4 Duke (23-2, 12-1 ACC) is coming off a 67-54 Saturday win over Clemson to maintain its spot atop the conference standings. Syracuse (15-11, 6-7 ACC) secured a one-point win over SMU on Feb. 14 following an overtime victory over Cal as Cuse is tied for ninth in the ACC.

Tipoff is at 7 p.m. ET from Cameron Indoor Stadium in Durham, N.C. The Blue Devils are 20.5-point favorites in the latest Syracuse vs. Duke odds from DraftKings Sportsbook, while the over/under for total points scored is 145.5, up two points from the opener. Before making any Duke vs. Syracuse picks, check out the men's college basketball predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every college basketball game 10,000 times and it enters Week 15 on a sizzling 11-1 run on its top-rated over/under college basketball picks dating back to last season, and is on an 11-5 run on top-rated CBB side picks. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.

Now, the model has simulated Syracuse vs. Duke 10,000 times and just revealed its coveted men's college basketball picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several men's college basketball odds and men's college basketball betting lines for Duke vs. Syracuse:

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How to make Duke vs. Syracuse picks

SportsLine's model has simulated Syracuse vs. Duke 10,000 times and is going Over on the total (145.5 points). This series tends to be high-scoring when taking place in North Carolina as their last five meetings in the state have averaged 157.6 combined points. That coincides with the Orange often engaging in shootouts when traveling as the Over is 7-3 in Syracuse road games this season. Over Syracuse's last 12 games overall, the Over sports a 9-3 record.

Meanwhile, Duke has the ACC's top scorer in Cameron Boozer (22.8 ppg) and the No. 6 2-point percentage (61.9%) in the country. However, Duke is susceptible to the outside shot as it ranks 230th (out of 365 teams) in made 3-pointers allowed per game. The model has the teams clearing 151 combined points as the total is surpassed in 73% of simulations.

The model also says one side of the spread hits over 50% of the time. You can only see that pick at SportsLine.

So who wins Duke vs. Syracuse, and which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the Syracuse vs. Duke spread to back, all from the advanced model that has simulated this game 10,000 times, and find out.